PEOPLE WITH MULTIPLE SCLEROSIS MAY BE AT INCREASED RISK OF DEVELOPING CANCER

Individuals with multiple sclerosis may have an increased risk of developing any type of cancer, with an especially high risk of developing breast cancer. That is the conclusion of a recent study published inEuropean Journal of Neurology. Because the findings contradict earlier studies, additional research is needed to determine whether a true link exists between multiple sclerosis and cancer

Previous research suggests that some individuals with autoimmune diseases may have an increased risk of developing cancer, but most studies have found no link between cancer and multiple sclerosis, an autoimmune disease that involves the central nervous system.

To investigate further, Li-Min Sun, MD, of the Zuoying Branch of Kaohsiung Armed Forces General Hospital in Kaohsiung, Taiwan, and his colleagues assessed data from the National Health Insurance System of Taiwan, including information on 1292 patients who were diagnosed with multiple sclerosis between 1997 and 2010. Each patient was matched with four participants without the condition.

"Our study was a nationwide population-based cohort study, and it revealed unexpected findings," said Dr. Sun. Specifically, the team found that individuals with multiple sclerosis were 85% more likely to develop cancer than the controls. Their risk of developing breast cancer was especially high, with more than a 2-fold increased risk over controls.

The findings suggest that patients with multiple sclerosis patients may need to be monitored closely to ensure early detection of cancer. Dr. Sun notes that it is unclear why his team's results are not consistent with most other studies. "The underlying genetic and environmental factors in Taiwan, which differ from those of western countries, might play an undetermined role. Additional large-scale studies will help improve our understanding," he said.

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BOWEL CANCER RISK REDUCED BY ADOPTING MULTIPLE HEALTHY BEHAVIORS

Adoption of a combination of five key healthy behaviors is associated with a reduction in the risk of developing bowel cancer. Researchers from the German Institute of Human Nutrition Potsdam-Rehbruecke quantified the impact of combined multiple healthy lifestyle behaviors on the risk of developing bowel cancer, and found that this impact is stronger in men than in women.

Lead author, Krasimira Aleksandrova, says: "These data provide additional incentive to individuals, medical professionals and public health authorities to invest in healthy lifestyle initiatives. Each person can contribute a lot to avoid cancer, the more healthy lifestyle changes, the better."

Bowel cancer, also called colorectal cancer, is the second most common cancer in men and the third most common cancer in women worldwide, with 55% cases occurring in developed regions such as North America and Western Europe. Previous studies have identified links between the cancer frequency rates and western lifestyles. However, most research has focused on isolated lifestyle behaviors, such as eating red meat, while little is known about the combined impact of lifestyle factors beyond their individual effects.

The research published in the open access journal BMC Medicine analyzed the data of 347,237 men and women from 10 countries from the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort study using a healthy lifestyle index. Over the 12-year study period, 3,759 cases of bowel cancer were recorded.

The healthy lifestyle index was composed by the following lifestyle factors: a healthy weight; low abdominal fat; participating in regular physical activity; not smoking and limiting alcohol; and a diet high in fruits, vegetables, fish, yoghurt, nuts and seeds, and foods rich in fiber, and low amounts of red and processed meat. For each of the five behaviors, study subjects were assigned one point for having the healthy factor and zero for not having the healthy factor. These points were then summed to generate a cumulative score for each participant.

Krasimira Aleksandrova, says: "Our data confirmed that with an increasing number of healthy lifestyle behaviors the risk that a person will have of developing bowel cancer decreases."

The researchers found that the more healthy lifestyle factors the cohort adopted, the lower their risk of bowel cancer. Compared to people who had followed up to one healthy lifestyle behavior, those who practiced a combination of two, three, four and all the five healthy behaviors had a 13%, 21%, 34% and 37% lower risk of developing bowel cancer, respectively. The authors noted a difference between men and women.

Krasimira Aleksandrova, says: "Estimates based on our study populations suggest that up to 22% of the cases in men and 11% of the cases in women would have been prevented if all five of the healthy lifestyle behaviors had been followed. Our results particularly demonstrate the potential for prevention in men who are at a higher risk of bowel cancer than women."