Today's post from allfordrugs.com (see link below) announces a new drug which may soon become available for treating neuropathy. It all depends on the outcomes fo the trials of course, so it may be some years before it appears on your doctor's prescription pad but it's always useful knowing what's in the pipeline. This one has the unattractive name of Z944 at the moment but that will undoubtedly change when its patented. The article itself may well seem like Martian for most people but the important words to remember are 'calcium channel blocker' because many of the drugs in current use or development are also calcium or sodium channel blockers. Googling will provide more information on this sort of pain signal blocker.
Nov 14th 2013
Biopharmaceutical firm Zalicus has started a Phase Ib clinical trial of Z944, a novel oral T-type calcium channel blocker, for the treatment of neuropathic pain.
The company expects to release the results from the laser-evoked potentials (LEP) study in the fourth quarter of 2013.
The study is designed to offer both objective and subjective data on a drug’s ability to modulate pain signalling.
http://www.drugdevelopment-technology.com/news/newszalicus-starts-phase-ib-clinical-trial-of-neuropathic-pain-drug
Z944 is a novel, oral, T-type calcium channel modulator that we are developing for pain.
Z944, an oral T-type Calcium Channel Modulator
Z944 is a novel, oral, state-dependent, selective T-type calcium channel modulator that has demonstrated efficacy in multiple preclinical inflammatory pain models and in a Phase 1b experimental model of pain. T-type calcium channels have been recognized as key targets for therapeutic intervention in a broad range of cell functions and have been implicated in pain signaling. Zalicus is planning to advance a modified release formulation of Z944 through further clinical development.
The wide distribution of T-type calcium channels found in brain, heart, endocrine cells and other tissues provides the possibility of developing therapeutics for multiple indications, including treatment of pain. Zalicus has utilized its expertise in this field to successfully discover high affinity, selective and orally available compounds, such as Z944, that show promise for further development.
T-type Calcium Channel Modulators
T-type, or transient-type (referring to the length of time activated), calcium channel modulators target low-voltage-activated, calcium channels. These channels have been recognized as critical components in numerous cell functions and have been implicated in the frequency and intensity of pain signals. Zalicus is investigating compounds to modulate T-type calcium channel signaling in the treatment of pain. Our orally-administered T-type calcium channel blockers have shown efficacy in animal models of acute, chronic and visceral pain, as well as other indications.
patent
WO2009146540
http://www.google.com/patents/WO2009146540A1
compd may be
N-[1-(N-tert-Butylcarbamoylmethyl)piperidin-4-ylmethyl]-3-chloro-5-fluorobenzamide
http://www.allfordrugs.com/2013/11/14/zalicus-starts-phase-ib-clinical-trial-of-neuropathic-pain-drug/
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